Reinberg A, Reinberg M A
Naunyn Schmiedebergs Arch Pharmacol. 1977 Mar;297(2):149-52. doi: 10.1007/BF00499924.
A statistically significant circadian rhythm of the duration of local anaesthesia produced by lidocaine and betoxycaine was found in both human skin and teeth. In adult subjects with diurnal activity and nocturnal rest the longest duration was found around 15.00 (3 p.m.) with a large peak-trough difference amounting to more than 100% of the 24 h mean. Such chronopharmacologic rhythm might be related to circadian rhythms in catecholamine secretion and/or in circadian changes of cell membrane properties.
在人体皮肤和牙齿中均发现，利多卡因和倍他卡因产生的局部麻醉持续时间存在具有统计学意义的昼夜节律。在白天活动、夜间休息的成年受试者中，最长持续时间出现在15:00（下午3点）左右，峰谷差异很大，超过24小时平均值的100%。这种时辰药理学节律可能与儿茶酚胺分泌的昼夜节律和/或细胞膜特性的昼夜变化有关。
