van der Burght M, Schønemann N K, Laursen J K, Arendt-Nielsen L, Bjerring P
Department of Anaesthesiology, University Hospital of Aarhus, Denmark.
Acta Derm Venereol. 1993 Dec;73(6):456-8. doi: 10.2340/0001555573456458.
The topical anaesthetic formulation EMLA cream (eutectic mixture of local anaesthetics) is increasingly used prior to minor painful procedures performed on genital mucosa. The aim of the present study was to gain knowledge about the correlation between duration of application of EMLA and duration of analgesia. Three different application times--5, 10 and 20 min--were investigated in 12 healthy young women. Pin-prick pain thresholds to argon laser stimulation were measured before and after application of EMLA. Repeated measurements were performed until normal sensitivity returned. No significant difference in duration of analgesia was seen between the three application times. However, 10 min application time tended to produce the longest mean duration of analgesia (22.2 min). Surprisingly, a large inter-individual variation in duration of analgesia was seen. Thus, after 10 min application time the shortest duration of sufficient analgesia was 5 min, while the longest was 46 min. On the basis of this work, it seems advisable to start minor surgery on genital mucosa after about 10 min application time, and it is recommended to bear in mind that the duration of analgesia varies and may be very short in some patients.
局部麻醉制剂EMLA乳膏（局部麻醉药的共熔混合物）越来越多地用于对生殖黏膜进行的小型疼痛手术之前。本研究的目的是了解EMLA的应用时间与镇痛持续时间之间的相关性。对12名健康年轻女性研究了三种不同的应用时间——5分钟、10分钟和20分钟。在应用EMLA之前和之后测量对氩激光刺激的针刺疼痛阈值。重复测量直至恢复正常敏感性。三种应用时间之间在镇痛持续时间上未见显著差异。然而，10分钟的应用时间往往产生最长的平均镇痛持续时间（22.2分钟）。令人惊讶的是，观察到镇痛持续时间存在很大的个体间差异。因此，在应用10分钟后，足够镇痛的最短持续时间为5分钟，而最长为46分钟。基于这项工作，似乎建议在应用约10分钟后开始对生殖黏膜进行小型手术，并且建议记住镇痛持续时间因人而异，在某些患者中可能非常短。
