Lin S C, Lin C C, Lin Y H, Supriyatna S, Teng C W
Department of Pharmacology, Taipei Medical College, Taiwan.
Am J Chin Med. 1995;23(3-4):243-54. doi: 10.1142/S0192415X95000298.
Curcuma xanthorrhiza Roxb. (Zingiberaceae family, commonly known as temu lawak or Javanese turmeric in Indonesia), which is found both wild and cultivated in Indonesia, has been traditionally used for medicinal purposes. C. xanthorrhiza is also used as a tonic in Indonesia. The aim of the present study is to clarify whether C. xanthorrhiza treatment may prevent acute liver damage induced by acetaminophen and carbon tetrachloride in mice. The results clearly indicated that extract of C. xanthorrhiza could reduce significantly the acute elevation of serum transaminases levels induced by the two kinds of hepatotoxins, and alleviated the degree of liver damage at 24 hours after the intraperitoneal administration of two hepatotoxins. It may be concluded that C. xanthorrhiza can protect the liver from various hepatotoxins, hence C. xanthorrhiza could be useful in the treatment of liver injuries and has promise as a kind of broad spectrum hepatoprotective agent.
郁金（姜科植物，在印度尼西亚通常被称为“temu lawak”或爪哇姜黄），在印度尼西亚既有野生的也有人工种植的，传统上一直被用于药用。在印度尼西亚，郁金也被用作滋补品。本研究的目的是阐明郁金治疗是否可以预防对乙酰氨基酚和四氯化碳诱导的小鼠急性肝损伤。结果清楚地表明，郁金提取物可以显著降低两种肝毒素诱导的血清转氨酶水平的急性升高，并减轻腹腔注射两种肝毒素后24小时的肝损伤程度。可以得出结论，郁金可以保护肝脏免受各种肝毒素的侵害，因此郁金可能对治疗肝损伤有用，并有望成为一种广谱肝保护剂。
