Lin S C, Lin C C, Lu F J, Lin Y H, Chen C H
Department of Pharmacology, Taipei Medical College, Taiwan.
Am J Chin Med. 1996;24(3-4):219-29. doi: 10.1142/S0192415X96000281.
The hepatoprotective effect of Huanglian-Jie-Du-Tang (HLJDT), a Chinese medicinal prescription, was investigated in three kinds of experimental models. The animals were treated with HLJDT (300 mg/kg, p.o.) thrice at 2, 4 and 10 hours after administration with carbon tetrachloride (32 microliters/kg, i.p.), acetaminophen (600 mg/kg, i.p.) and beta-D-galactosamine (188 mg/kg, i.p.). Significant hepatoprotective effects on carbon tetrachloride and acetaminophen induced liver injuries were noted, but no significant effect on beta-D-galactosamine induced liver injury was observed. These hepatoprotective effects were evidenced by comparing the serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) levels in HLJDT treated and untreated groups. Serum enzyme activities in the carbon tetrachloride and acetaminophen experiments were significantly lower in the treated groups while the herbal prescription has no effect on the beta-D-galactosamine experiment. These results demonstrated that Huanglian-Jie-Du-Tang has a hepatoprotective effect against experimental liver injuries induced by specific hepatotoxins, and therefore may be useful in treating some, but not all, liver injuries.
在三种实验模型中研究了中药方剂黄连解毒汤（HLJDT）的肝保护作用。在腹腔注射四氯化碳（32微升/千克）、对乙酰氨基酚（600毫克/千克）和β-D-半乳糖胺（188毫克/千克）后2小时、4小时和10小时，给动物口服HLJDT（300毫克/千克）三次。观察到HLJDT对四氯化碳和对乙酰氨基酚诱导的肝损伤具有显著的肝保护作用，但对β-D-半乳糖胺诱导的肝损伤没有显著作用。通过比较HLJDT处理组和未处理组的血清谷草转氨酶（SGOT）和血清谷丙转氨酶（SGPT）水平，证实了这些肝保护作用。在四氯化碳和对乙酰氨基酚实验中，处理组的血清酶活性显著降低，而该中药方剂对β-D-半乳糖胺实验没有影响。这些结果表明，黄连解毒汤对特定肝毒素诱导的实验性肝损伤具有肝保护作用，因此可能对治疗某些（而非全部）肝损伤有用。
