灵芝和云芝对γ射线照射小鼠脾脏T细胞亚群的影响。

Effects of Ganoderma lucidum and krestin on subset T-cell in spleen of gamma-irradiated mice.

作者信息

Chen W C, Hau D M, Wang C C, Lin I H, Lee S S

机构信息

Institute of Radiation Biology, National Tsing Hua University, Hsinchu, Taiwan.

出版信息

Am J Chin Med. 1995;23(3-4):289-98. doi: 10.1142/S0192415X95000341.

DOI:10.1142/S0192415X95000341

PMID:8571925

Abstract

Effects of Ganoderma lucidum (Gl) and Krestin (PSK) extracts on spleen, thymus and splenocytes in gamma-irradiated mice were investigated in this study. ICR strain male mice were divided into five groups. Group A was the normal control. Group B, the experimental control, was treated with Gl. Group C, the radiation treatment control, was treated with whole body exposure to 4 Gy gamma-irradiation (RT). Group D was treated with RT and Gl. Group E was treated with RT and PSK. The dosage of Gl was 400 mg/day/kg body weight and PSK was 500 mg/day/kg body weight. Our results indicated that the relative thymus weight in groups D and E were higher than group C on day 28 after gamma-irradiation. Group D was the highest in all the experimental groups. CD4 and CD8 splenocytes in group D were higher than group C on days 7 and 28. Gl was better than PSK in repairing the damage of subset T-cells in the spleen of gamma-irradiated mice.

摘要

本研究调查了灵芝（Gl）和云芝多糖（PSK）提取物对γ射线照射小鼠脾脏、胸腺和脾细胞的影响。将ICR品系雄性小鼠分为五组。A组为正常对照组。B组为实验对照组，用Gl处理。C组为辐射治疗对照组，接受全身4 Gy γ射线照射（RT）。D组接受RT和Gl处理。E组接受RT和PSK处理。Gl的剂量为400 mg/天/千克体重，PSK的剂量为500 mg/天/千克体重。我们的结果表明，γ射线照射后第28天，D组和E组的相对胸腺重量高于C组。D组在所有实验组中最高。γ射线照射后第7天和第28天，D组的CD4和CD8脾细胞高于C组。在修复γ射线照射小鼠脾脏中T细胞亚群的损伤方面，Gl优于PSK。