甘草及甘草酸对小鼠辐射损伤的影响。

Effects of Glycyrrhizae and Glycyrrhizic acid on radiation injury in mice.

作者信息

Lin I H, Hau D M, Su M J, Chen W C

机构信息

Institute of Radiation Biology, National Tsing-Hua University, Hsinchu, Taiwan.

出版信息

Am J Chin Med. 1996;24(3-4):279-88. doi: 10.1142/S0192415X96000347.

DOI:10.1142/S0192415X96000347

PMID:8982440

Abstract

The effects of Glycyrrhizae (GL) and Glycyrrhizic acid (GA) on promoting the recovery of mice from radiation injury were investigated. Two hundred ICR strain male mice, 6-8 weeks old, were randomly divided into four groups. Group A was the normal control. Group B, the experimental control, was treated with 4 Gy gamma-ray irradiation. Groups C and D, the experimental groups, were treated with 500 mg/kg of GL (oral administration) and 5 mg/kg body weight of GA (i.p.), respectively, for ten days after gamma-ray irradiation. Eight mice in each group were sacrificed on days 5, 12, 26 and 33 post irradiation to measure the weights of spleen, thymus and testes, and the biosynthetic rates of DNA in these organs. The results revealed that 4 Gy gamma-ray irradiation evidently inhibited the weights of spleen, thymus and testes, and their DNA biosynthetic rates. GL and GA enhanced the recovery of these organs in mice from the injury of gamma-ray irradiation.

摘要

研究了甘草（GL）和甘草酸（GA）对促进小鼠辐射损伤恢复的作用。将200只6-8周龄的ICR品系雄性小鼠随机分为四组。A组为正常对照组。B组为实验对照组，接受4 Gyγ射线照射。C组和D组为实验组，分别在γ射线照射后连续10天给予500 mg/kg的GL（口服）和5 mg/kg体重的GA（腹腔注射）。每组8只小鼠在照射后第5、12、26和33天处死，测量脾脏、胸腺和睾丸的重量以及这些器官中DNA的生物合成率。结果显示，4 Gyγ射线照射明显抑制了脾脏、胸腺和睾丸的重量及其DNA生物合成率。GL和GA促进了小鼠这些器官从γ射线照射损伤中的恢复。