Harris J P, Aframian D
Department of Surgery, University of California, San Diego, USA.
Am J Otol. 1994 Nov;15(6):710-6.
Contralateral delayed endolymphatic hydrops is described as the development of fluctuating hearing loss and episodic vertigo in a normal ear years following sensorineural hearing loss in the opposite ear. This condition is a variant of delayed endolymphatic hydrops in which new symptoms of severe episodic vertigo develop years later in an ear that has lost most or all of its hearing. The possible etiologies of these two conditions are unknown and may be different. This report presents seven cases of the contralateral form of this disease and experimental evidence that suggests that these patients may be suffering from the initiation of an autoimmune event directed against the remaining inner ear. In Western blot analysis, their serum was reacted against cow cochlear inner ear antigen preparations, and six of the seven cases had serum antibodies directed against a 68 or a 35-36 kilodalton (kd) molecular weight antigen in contrast to three of 43 normal controls (p < .001 Fisher's exact test), the significance of which had previously been reported for autoimmune inner ear disease.
对侧迟发性内淋巴积水被描述为在对侧耳发生感音神经性听力损失数年之后，正常耳出现波动性听力损失和发作性眩晕。这种情况是迟发性内淋巴积水的一种变体，即在一只已丧失大部分或全部听力的耳朵中，数年后出现严重发作性眩晕的新症状。这两种情况的可能病因尚不清楚，且可能有所不同。本报告介绍了7例该病的对侧形式病例以及实验证据，这些证据表明这些患者可能正遭受针对剩余内耳的自身免疫事件的起始阶段。在蛋白质印迹分析中，他们的血清与牛耳蜗内耳抗原制剂发生反应，7例病例中有6例血清抗体针对分子量为68或35 - 36千道尔顿（kd）的抗原，相比之下，43名正常对照中有3例（Fisher精确检验，p < .001），其意义先前已在自身免疫性内耳疾病中报道过。
