非洲爪蟾卵激活过程中蛋白酶体的激活意味着蛋白酶体激活与细胞内钙释放之间存在联系。
Activation of the proteasome during Xenopus egg activation implies a link between proteasome activation and intracellular calcium release.
作者信息
Aizawa H, Kawahara H, Tanaka K, Yokosawa H
机构信息
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
出版信息
Biochem Biophys Res Commun. 1996 Jan 5;218(1):224-8. doi: 10.1006/bbrc.1996.0039.
Ubiquitin-dependent proteolysis is required for cell cycle progression. Here, we demonstrate that the proteasome is activated during in vivo Xenopus egg activation, induced by treatment with the calcium ionophore A23187. It was found that activation is due to the calcium-induced assembly of the 26 S proteasome from the 20 S proteasome. We propose that proteasome activation is regulated by cell cycle calcium transients, which are controlled upstream by an endogenous cell cycle oscillator that is independent of the cyclin-dependent kinase cycle.
泛素依赖性蛋白水解是细胞周期进程所必需的。在此，我们证明蛋白酶体在体内爪蟾卵激活过程中被激活，该激活由钙离子载体A23187处理诱导。研究发现，激活是由于钙离子诱导20S蛋白酶体组装成26S蛋白酶体。我们提出蛋白酶体激活受细胞周期钙瞬变调节，而细胞周期钙瞬变由一个独立于细胞周期蛋白依赖性激酶周期的内源性细胞周期振荡器在上游控制。
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