Srinivas V, Orihuela E, Lloyd K O, Old L J, Whitmore W F
J Urol. 1985 Jan;133(1):25-8. doi: 10.1016/s0022-5347(17)48770-2.
ABO(H) isoantigen expression was estimated semiquantitatively with the red cell adherence test on single epithelial cell suspensions from 89 bladder tumor and 7 normal bladder specimens. Correlations of red cell adherence counts positive for antigen with the pathological findings of the bladder (histology and stage of tumor) were made in a blind fashion at the end of the study. The mean count positive for antigen from normal bladders was 86.0, which was significantly different (p less than 0.001) from those of muscle-invading lesions (12.6) and flat carcinoma in situ (21.6). This study shows a good correlation among the cell counts positive for antigen, histological findings and stage of disease, and provides the basis for a prospective study that may help to determine the role of ABO(H) isoantigen measurement in bladder tumor patients.
采用红细胞黏附试验对89份膀胱肿瘤标本和7份正常膀胱标本的单个上皮细胞悬液进行ABO(H)同种抗原表达的半定量评估。研究结束时，以盲法将抗原阳性的红细胞黏附计数结果与膀胱的病理检查结果（肿瘤组织学类型和分期）进行关联分析。正常膀胱抗原阳性计数的平均值为86.0，与肌层浸润性病变（12.6）和原位扁平癌（21.6）相比有显著差异（p<0.001）。本研究表明抗原阳性细胞计数、组织学检查结果和疾病分期之间具有良好的相关性，并为一项前瞻性研究提供了依据，该研究可能有助于确定ABO(H)同种抗原检测在膀胱肿瘤患者中的作用。
