Araki S, Kikkawa R, Haneda M, Koya D, Togawa M, Liang P M, Shigeta Y
Third Department of Medicine, Shiga University of Medical Science, Japan.
J Diabetes Complications. 1995 Oct-Dec;9(4):323-5. doi: 10.1016/1056-8727(95)80032-a.
In order to examine whether the existence of microalbuminuria can predict the development of overt proteinuria and cardiovascular death in Japanese subjects with non-insulin-dependent diabetes mellitus (NIDDM), we investigated 47 patients for a 10-year follow-up period. Patients were divided into two groups by the initial values of urinary albumin excretion rates. The percentage of patients who developed overt proteinuria during the follow-up period was significantly higher in patients who were initially classified as microalbuminuric group (63.6%) than in normoalbuminuric group (17.4%). During the follow-up period, one of the patients with normoalbuminuria had died of congestive heart failure, while four of those with microalbuminuria had died; one of stroke and three from noncardiovascular diseases. These results indicate that the existence of microalbuminuria had the predictive power for the development of overt proteinuria, but not for cardiovascular death in Japanese subjects with NIDDM.
为了研究微量白蛋白尿的存在是否能够预测日本非胰岛素依赖型糖尿病（NIDDM）患者显性蛋白尿的发生及心血管死亡情况，我们对47例患者进行了为期10年的随访。根据尿白蛋白排泄率的初始值将患者分为两组。在随访期间，最初被归类为微量白蛋白尿组的患者中出现显性蛋白尿的比例（63.6%）显著高于正常白蛋白尿组（17.4%）。在随访期间，正常白蛋白尿组中有1例患者死于充血性心力衰竭，而微量白蛋白尿组中有4例患者死亡；其中1例死于中风，3例死于非心血管疾病。这些结果表明，微量白蛋白尿的存在对日本NIDDM患者显性蛋白尿的发生具有预测能力，但对心血管死亡没有预测能力。
