Cook R W
Vet Pathol. 1977 Mar;14(2):138-45. doi: 10.1177/030098587701400206.
A 10-month-old female, Wire-haired Pointing Griffon dog had a hamartoma of the hypothalamus. Episodes of sudden flaccid collapse had increased in frequency and duration for 7 months. Cerebrospinal fluid pressure was normal. A flat, pedunculated mass, 2.5 X 3.0 X 0.9 cm, covered the brain stem between the pituitary gland and pons. Its 1.2-cm-diameter connection to the hypothalamus obliterated the mammillary bodies and extended to the tuber cinereum, distorting the hypothalamus and displacing the third ventricle which also divided the rostral part of the mass. The tissue of the hamartoma resembled gray matter with bullous cytoplasmic vacuolation of many neurons, spongiform change, gemistocytosis and microscopic foci of calcification.
一只10个月大的刚毛指示格里芬犬患有下丘脑错构瘤。突然弛缓性虚脱发作的频率和持续时间在7个月内有所增加。脑脊液压力正常。一个扁平的带蒂肿块，大小为2.5×3.0×0.9厘米，覆盖了垂体和脑桥之间的脑干。其与下丘脑直径1.2厘米的连接使乳头体消失，并延伸至灰结节，使下丘脑变形并移位第三脑室，第三脑室也将肿块的头侧部分分开。错构瘤组织类似于灰质，许多神经元有大疱性细胞质空泡形成、海绵状改变、肥胖细胞增多和微小钙化灶。
