Desangles F, Vilain E, Arborio M, De Revel T, Flandrin G
Laboratoire de Biologie Clinique, HIA Val de Grâce, Paris, France.
Leuk Lymphoma. 1995 Sep;19(1-2):185-8. doi: 10.3109/10428199509059675.
This report describes a case of acute promyelocytic leukemia (APL) M3. At diagnosis, the specific t(15;17) translocation was observed. After chemotherapy including retinoic acid, a complete remission was achieved and the karyotype became normal. At relapse of the M3 leukemia, the t(15;17) clone was no longer observed but a t(3;6) translocation was then detected. Several hypotheses for this unusual cytogenetic course of APL are discussed.
本报告描述了一例急性早幼粒细胞白血病（APL）M3型病例。诊断时，观察到特异性t(15;17)易位。在包括维甲酸在内的化疗后，实现了完全缓解，核型恢复正常。在M3白血病复发时，未再观察到t(15;17)克隆，但随后检测到t(3;6)易位。本文讨论了APL这种不寻常细胞遗传学过程的几种假说。
