A unique case of t(15;17) acute promyelocytic leukaemia (M3) developing into acute myeloblastic leukaemia (M1) with t(7;21) at relapse.

作者信息

Jubashi T, Nagai K, Miyazaki Y, Nakamura H, Matsuo T, Kuriyama K, Tomonaga M

机构信息

Department of Haematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan.

出版信息

Br J Haematol. 1993 Apr;83(4):665-8. doi: 10.1111/j.1365-2141.1993.tb04709.x.

This report describes a case of t(15;17) acute promyelcytic leukaemia (APL, FAB subtype M3) with dysgranulopoiesis at diagnosis in a patient who developed myelodysplasia (MDS) and then a second phenotype of t(7;21) acute myeloblastic leukaemia (AML, FAB subtype M1) at the time of relapse. To our knowledge, there is no report of a second phenotype of AML occurring after complete remission (CR) of APL. Furthermore, this is the first report of chromosomal abnormality t(7;21) in a case of AML. Several hypotheses for this unusual course of APL are discussed.