Ferreira L M, Anthony J P, Mathes S, Andrews J M, Laredo Filho J
Departamento de Cirurgia, Universidade Federal de São Paulo-Escola Paulista de Medicina.
Rev Assoc Med Bras (1992). 1995 May-Jun;41(3):213-8.
To analyze the composite tissue vascularized allotransplantation post operative complications and to identify factors associated with agents toxicity.
The study was done across a strong histocompatibility barrier using 39 Brown-Norway rats as donors and 78 Fischer 344 as hindlimb allotransplantation recipients treated with cyclosporine and RS-61443.
1 (1/78: 1.28%) was eliminated owing to thrombosis; 2 (2/78: 2.56%) owing to enteritis; 1 (1/78: 1.28%) owing to autophagia and 8 (8/78: 10.42%) died owing to undiscovered cause.
Among 78 (78/78: 100%) rat limb vascularized allotransplantations, 12 (15.5%) rats died or were eliminated because of acute postoperative complications that were not related to rejection, to immunosuppressive toxicity or to opportunistic infection.
分析复合组织血管化同种异体移植术后并发症，并确定与药物毒性相关的因素。
本研究跨越强大的组织相容性屏障，使用39只棕色挪威大鼠作为供体，78只Fischer 344大鼠作为后肢同种异体移植受体，接受环孢素和RS - 61443治疗。
1只（1/78：1.28%）因血栓形成被淘汰；2只（2/78：2.56%）因肠炎被淘汰；1只（1/78：1.28%）因自噬被淘汰，8只（8/78：10.42%）因不明原因死亡。
在78只（78/78：100%）大鼠肢体血管化同种异体移植中，12只（15.5%）大鼠因与排斥反应、免疫抑制毒性或机会性感染无关的急性术后并发症死亡或被淘汰。
