Watanabe K, Iwatani Y, Hidaka Y, Watanabe M, Amino N
Department of Laboratory Medicine, Osaka University Medical School, Japan.
Endocr J. 1995 Oct;42(5):661-8. doi: 10.1507/endocrj.42.661.
We examined the effects of the long-term administration to mice of thyroid hormone or propylthiouracil (PTU) on lymphocyte subsets in spleens, and thymuses to clarify whether hyperthyroxinemia itself causes the changes in lymphocyte subsets, such as the marked increase in CD5+ B cells and decrease in natural killer (NK) cells, observed in hyperthyroid Graves' disease. Both the number and proportion of splenic NK (Thy-1+ asialo GM1+) cells were increased in hyperthyroxinemic mice treated with thyroxine (T4) for both short and long terms (8 and 32 weeks, respectively), those of splenic and thymic T (CD5+ sIgM-) cells and CD5-B cells were increased only in hypothyroxinemic mice treated with PTU for 32 weeks, compared with those in euthyroid mice. These data indicate that 1) long-term hyperthyroxinemia increases splenic and thymic T cells and splenic NK cells, but not CD5+ B cells, in mice, 2) long-term hypothyroxinemia induced by PTU treatment increases splenic B cells and CD5- B cells, and 3) hyperthyroxinemia itself does not cause the changes in CD5+ B cells and NK cells, which are observed in hyperthyroid Graves' disease, in mice.
我们研究了长期给小鼠注射甲状腺激素或丙硫氧嘧啶（PTU）对脾脏和胸腺中淋巴细胞亚群的影响，以阐明甲状腺素血症本身是否会导致淋巴细胞亚群的变化，如在甲状腺功能亢进的格雷夫斯病中观察到的CD5 + B细胞显著增加和自然杀伤（NK）细胞减少。短期和长期（分别为8周和32周）用甲状腺素（T4）治疗的甲状腺素血症小鼠，脾脏NK（Thy-1 + 去唾液酸GM1 +）细胞的数量和比例均增加；与甲状腺功能正常的小鼠相比，仅在接受PTU治疗32周的甲状腺功能减退小鼠中，脾脏和胸腺T（CD5 + sIgM-）细胞以及CD5 - B细胞的数量和比例增加。这些数据表明：1）长期甲状腺素血症会增加小鼠脾脏和胸腺中的T细胞以及脾脏NK细胞，但不会增加CD5 + B细胞；2）PTU治疗诱导的长期甲状腺功能减退会增加脾脏B细胞和CD5 - B细胞；3）甲状腺素血症本身不会导致小鼠出现甲状腺功能亢进的格雷夫斯病中观察到的CD5 + B细胞和NK细胞的变化。
