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[肝硬化——分类、病因、发病机制、进展、可逆性]

[Liver cirrhosis--classification, etiology, pathogenesis, progress, reversibility].

作者信息

Holle G

出版信息

Z Gesamte Inn Med. 1977 Jan 1;32(1):1-10.

PMID:857441
Abstract

On the basis of our modern knowledge of structure and function of the liver at first the cause of the liver cirrhosis and the essential possibilities of classification are discussed. A further important problem is the question of progression and regression of the liver cirrhosis. Here special immunomechanisms play a part, the possible influences of which on a progressing of the disease are demonstrated in detail. Of particular importance are, apart from this, the influence of the virus hepatitis and the question, how many liver cirrhoses are of hepatitic genesis. Also, the importance of alcohol and the mechanisms which from an alcoholic liver damage form a cirrhosis are treated. Finally the author deals with the evidence of the diagnostics of biopsy, in which case, apart from the diagnostics, first of all the prognostic judgment of the development of the cirrhotic process is of importance.

摘要

基于我们对肝脏结构和功能的现代认识,首先讨论肝硬化的病因及分类的基本可能性。另一个重要问题是肝硬化的进展和消退问题。这里特殊的免疫机制起作用,详细阐述了其对疾病进展可能产生的影响。除此之外,尤其重要的是病毒性肝炎的影响以及有多少肝硬化是由肝炎引起的问题。此外,还探讨了酒精的影响以及酒精性肝损伤形成肝硬化的机制。最后,作者论述了活检诊断的依据,在这种情况下,除诊断外,首先对肝硬化进程发展的预后判断至关重要。

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