Bitterman N, Schaal S
Israel Naval Medical Institute, Haifa, Israel.
Brain Res. 1995 Oct 23;696(1-2):250-3. doi: 10.1016/0006-8993(95)00820-g.
We tested the effect of caffeine, on hyperoxia-induced seizures. Thirty-seven rats with chronic cortical electrodes were injected i.p. with caffeine (1.25, 2.5, and 10 mg/kg) or vehicle before exposure to 0.5 MPa oxygen and 17 rats to oxygen with 5% CO2 at 0.5 MPa. EEG monitoring and spectral analysis of EEG activity were carried out. Caffeine significantly prolonged the latent period to the onset of seizures (P < 0.05 in ANOVA), in a dose-related manner. Our results suggest that caffeine may be used in low doses for protection against hyperoxia-induced seizures.
我们测试了咖啡因对高氧诱导癫痫发作的影响。对37只植入慢性皮层电极的大鼠腹腔注射咖啡因（1.25、2.5和10mg/kg）或赋形剂，然后将其置于0.5MPa氧气环境中，另有17只大鼠置于含5%二氧化碳的0.5MPa氧气环境中。进行脑电图（EEG）监测及EEG活动的频谱分析。咖啡因能显著延长癫痫发作的潜伏期（方差分析中P<0.05），且呈剂量相关。我们的结果表明，低剂量咖啡因可用于预防高氧诱导的癫痫发作。
