Karlsson K A
Göteborg University, Sweden.
Curr Opin Struct Biol. 1995 Oct;5(5):622-35. doi: 10.1016/0959-440x(95)80054-9.
Attachment of microbial protein to host cell-surface carbohydrate is considered essential for successful infection. Information of conceptual interest, including crystal structures of protein-saccharide complexes and convincing models of target membrane penetration, continues to emerge for viruses and bacterial toxins. Other important data relate to therapeutic receptor blockade, through the use of saccharide analogs or vaccines directed against the microbial adhesin.
微生物蛋白与宿主细胞表面碳水化合物的附着被认为是成功感染所必需的。对于病毒和细菌毒素，包括蛋白质-糖类复合物的晶体结构以及令人信服的靶膜穿透模型等具有概念性意义的信息不断涌现。其他重要数据涉及通过使用糖类似物或针对微生物粘附素的疫苗进行治疗性受体阻断。
