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两个参与粟酒裂殖酵母有性发育的新基因。

Two novel genes involved in the sexual development of Schizosaccharomyces pombe.

作者信息

Molnar M, Sipiczki M

机构信息

Department of Genetics, and Institute of Biology, University of Debrecen, Hungary.

出版信息

Curr Genet. 1995 Oct;28(5):447-53. doi: 10.1007/BF00310814.

DOI:10.1007/BF00310814
PMID:8575018
Abstract

We isolated two sterile mutants of Schizosaccharomyces pombe. One of them was mapped close to ste13 (8 cM). Since it turned out to be allelic with the hitherto unmapped ral2, its linkage with ste13 localizes ral2 on the right arm of chromosome II. The other mutant defines a novel class-I ste gene, ste15, closely linked to ste7 (4 cM) on chromosome I. ste15 is conjugation-specific and acts upstream of pat1 and ras1. During its genetic analysis, a phenotypic suppression of ste12-N9 was observed which was caused by mutations in the unlinked gene ssw1.

摘要

我们分离出了粟酒裂殖酵母的两个无菌突变体。其中一个被定位在靠近ste13(8厘摩)的位置。由于它被证明与迄今未定位的ral2等位,其与ste13的连锁关系将ral2定位在第二条染色体的右臂上。另一个突变体定义了一个新的I类ste基因ste15,它与第一条染色体上的ste7紧密连锁(4厘摩)。ste15是接合特异性的,作用于pat1和ras1上游。在其遗传分析过程中,观察到ste12-N9的表型抑制,这是由非连锁基因ssw1中的突变引起的。

相似文献

1
Two novel genes involved in the sexual development of Schizosaccharomyces pombe.两个参与粟酒裂殖酵母有性发育的新基因。
Curr Genet. 1995 Oct;28(5):447-53. doi: 10.1007/BF00310814.
2
The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe.不育基因(ste和aff)在粟酒裂殖酵母有性发育起始过程中的作用。
Mol Gen Genet. 1988 Aug;213(2-3):529-34. doi: 10.1007/BF00339626.
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The ste13+ gene encoding a putative RNA helicase is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development in the fission yeast Schizosaccharomyces pombe.编码一种假定RNA解旋酶的ste13+基因对于裂殖酵母粟酒裂殖酵母中氮饥饿诱导的G1期停滞和有性发育的起始至关重要。
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ras1 and pat1 alleles interact to quantitatively and qualitatively alter conjugation in fission yeast.ras1和pat1等位基因相互作用,在数量和质量上改变裂殖酵母中的接合作用。
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引用本文的文献

1
Rapamycin specifically interferes with the developmental response of fission yeast to starvation.雷帕霉素特异性干扰裂殖酵母对饥饿的发育反应。
J Bacteriol. 1997 Oct;179(20):6325-34. doi: 10.1128/jb.179.20.6325-6334.1997.

本文引用的文献

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Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe.RAS与G蛋白在粟酒裂殖酵母性反应途径中的协同作用。
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The ste13+ gene encoding a putative RNA helicase is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development in the fission yeast Schizosaccharomyces pombe.编码一种假定RNA解旋酶的ste13+基因对于裂殖酵母粟酒裂殖酵母中氮饥饿诱导的G1期停滞和有性发育的起始至关重要。
Mol Gen Genet. 1994 Sep 1;244(5):456-64. doi: 10.1007/BF00583896.
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J Gen Microbiol. 1980 Feb;116(2):525-8. doi: 10.1099/00221287-116-2-525.
10
Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast.在裂殖酵母中,该基因在G1期对细胞周期进程是必需的,在G2期对有丝分裂的控制是必需的。
Nature. 1981 Aug 6;292(5823):558-60. doi: 10.1038/292558a0.