Institute of Medical Science, University of Tokyo, P.O. Takanawa, Tokyo 108, Japan.
EMBO J. 1986 Aug;5(8):1991-3. doi: 10.1002/j.1460-2075.1986.tb04454.x.
We demonstrate that a diffusible factor is secreted by h cells of the fission yeast Schizosaccharomyces pombe, whose mating pheromones have not been described. This factor, tentatively named the h-factor, affects hS. pombe cells and induces their elongation under nitrogen-depleted conditions. Circumstantial evidence suggests its physiological significance in the mating process. Despite their sterility, hras1 cells secrete this factor. However, hras1 cells have apparently lost the ability to respond to it. This may suggest that the gene product of S. pombe ras1, a homologue of mammalian ras oncogenes, is involved in the mechanism for responding to mating pheromones.
我们证实，一种可扩散因子由裂殖酵母 Schizosaccharomyces pombe 的 h 细胞分泌，但其交配信息素尚未被描述。该因子暂定名为 h 因子，可影响 hS.pombe 细胞并在氮饥饿条件下诱导其伸长。间接证据表明其在交配过程中的生理意义。尽管 hras1 细胞不育，但仍分泌该因子。然而，hras1 细胞显然失去了对其的响应能力。这可能表明，裂殖酵母 ras1 的基因产物，哺乳动物 ras 癌基因的同源物，参与了响应交配信息素的机制。
