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Human buccal epithelial cells as a potential biochemical predictor of essential hypertension: identification of key cellular processes.

作者信息

McMurchie E J, Head R J

机构信息

CSIRO (Australia), Division of Human Nutrition, Adelaide, Australia.

出版信息

Clin Exp Pharmacol Physiol. 1995 Oct;22(10):772-4. doi: 10.1111/j.1440-1681.1995.tb01934.x.

DOI:10.1111/j.1440-1681.1995.tb01934.x
PMID:8575116
Abstract
  1. Human cheek cell Na+/H+ antiporter activity (measured as the rate of proton-dependent 22Na+ uptake) was determined in seven normotensive (NT) and four hypertensive (HT) subjects following preincubation of cheek cells with a low molecular weight fraction isolated from NT saliva together with the ionophore, nigericin. 2. Cheek cells preincubated in this manner exhibited greater Na+/H+ antiporter activity with the mean values being 4.2 nmol Na+.mg protein.5 min for the NT group and 1.7 for the HT group. 3. It is possible that stimulation of Na+ transport is due to cellular accumulation of K+ ions during preincubation which, in the presence of the K+/H+ selective ionophore, nigericin, can cause cellular reacidification promoting further 22Na+ uptake via the Na+/H+ antiporter.
摘要

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引用本文的文献

1
Stimulation of human cheek cell Na+/H+ antiporter activity by saliva and salivary electrolytes: amplification by nigericin.唾液和唾液电解质对人颊细胞钠氢交换体活性的刺激：尼日利亚菌素的放大作用。
Mol Cell Biochem. 1996 Jan 26;154(2):133-41. doi: 10.1007/BF00226781.