Shimizu E, Nakabayashi I, Kubota T, Suzuki Y, Shimizu J, Ishida A, Yoshida M, Yoshizawa N
Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Clin Nephrol. 1995 Oct;44(4):266-70.
We describe 2 patients with pauci-immune crescentic glomerulonephritis and elevated titers of perinuclear and cytoplasmic anti-neutrophil cytoplasmic antibody (P-ANCA and C-ANCA) which were associated with both 29 and 59 kD bands on Western blots. The presence of C-ANCA corresponds with a clinical and/or histological diagnosis of Wegener's granulomatosis, but although both patients suffered from pulmonary complications there was no clinical nor histological evidence of granulomatosis. Transbronchial lung biopsy showed only interstitial pneumonia and old hemorrhage. Therefore, the patients' conditions were interpreted as microscopic polyarteritis nodosa or hitherto undefined vasculitis associated with ANCA.
我们描述了2例寡免疫性新月体性肾小球肾炎患者，其核周型和胞浆型抗中性粒细胞胞浆抗体（P-ANCA和C-ANCA）滴度升高，在免疫印迹上与29kD和59kD条带相关。C-ANCA的存在与韦格纳肉芽肿的临床和/或组织学诊断相符，但尽管这2例患者均有肺部并发症，但并无肉芽肿病的临床及组织学证据。经支气管肺活检仅显示间质性肺炎和陈旧性出血。因此，患者的病情被解释为显微镜下结节性多动脉炎或迄今未明确的与ANCA相关的血管炎。
