Timár J, Diczházi C, Ladányi A, Rásó E, Hornebeck W, Robert L, Lapis K
1st Institute of Pathology & Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary.
Ciba Found Symp. 1995;192:321-35; discussion 335-7.
It is now well established that the interaction of tumour cells with elastin is important during invasion and metastasis. This is due to the fact that the elastin receptor complex is widely expressed by tumour cells and is overexpressed in highly metastatic variants. There is evidence that the elastin receptor complex is associated with a signal system involving G proteins, phospholipase C, the phosphoinositol cycle and protein kinase C. Therefore, activation of the elastin receptor system results in activation of protein kinase C-dependent cellular processes such as enzyme secretion and migration. Accordingly, soluble elastin can be used in vivo to interfere with tumour cell dissemination into elastin-rich tissues such as lung, skin or blood vessels. The importance of elastin-tumour cell interactions is emphasized by the observation that the 67 kDa receptor for laminin may well be identical to the 67 kDa elastin receptor of the elastin receptor complex. Interference with the function of this receptor system by the use of both laminin peptides and elastin ligands may provide the basis for a novel and more powerful antimetastatic intervention.
目前已经充分证实，肿瘤细胞与弹性蛋白的相互作用在侵袭和转移过程中至关重要。这是因为弹性蛋白受体复合物在肿瘤细胞中广泛表达，并且在高转移性变体中过度表达。有证据表明，弹性蛋白受体复合物与一个涉及G蛋白、磷脂酶C、磷酸肌醇循环和蛋白激酶C的信号系统相关。因此，弹性蛋白受体系统的激活会导致蛋白激酶C依赖性细胞过程的激活，如酶分泌和迁移。相应地，可溶性弹性蛋白可在体内用于干扰肿瘤细胞向富含弹性蛋白的组织（如肺、皮肤或血管）的扩散。层粘连蛋白的67 kDa受体很可能与弹性蛋白受体复合物的67 kDa弹性蛋白受体相同，这一观察结果强调了弹性蛋白与肿瘤细胞相互作用的重要性。通过使用层粘连蛋白肽和弹性蛋白配体来干扰该受体系统的功能，可能为一种新型且更有效的抗转移干预措施提供基础。
