Duca Laurent, Floquet Nicolas, Alix Alain J P, Haye Bernard, Debelle Laurent
Université de Reims Champagne Ardenne, IFR53 Biomolécules, UFR Sciences Exactes et Naturelles, FRE CNRS 2534, Moulin de la Housse, BP 1039, 51687 Reims Cedex 2, France.
Crit Rev Oncol Hematol. 2004 Mar;49(3):235-44. doi: 10.1016/j.critrevonc.2003.09.007.
The fact that elastin peptides, the degradation products of the extracellular matrix protein elastin, are chemotactic for numerous cell types, promote cell cycle progression and induce release of proteolytic enzymes by stromal and cancer cells, strongly suggests that their presence in tissues could contribute to tumour progression. Thus, elastin peptides qualify as matrikines, i.e. peptides originating from the fragmentation of matrix proteins and presenting biological activities. After a brief description of their origin, the biological activities of these peptides are reviewed, emphasising their potential role in cancer. The nature of their receptor and the signalling events it controls are also discussed. Finally, the structural selectivity of the elastin complex receptor is presented, leading to the concept of elastokine (matrikine originating from elastin fragmentation) and morpho-elastokine, i.e. peptides presenting a conformation similar to that of bioactive elastin peptides and mimicking their effects.
细胞外基质蛋白弹性蛋白的降解产物弹性蛋白肽对多种细胞类型具有趋化作用，可促进细胞周期进程，并诱导基质细胞和癌细胞释放蛋白水解酶，这一事实强烈表明它们在组织中的存在可能有助于肿瘤进展。因此，弹性蛋白肽可被视为基质因子，即源自基质蛋白片段化并具有生物活性的肽。在简要描述其来源后，本文对这些肽的生物活性进行了综述，重点强调了它们在癌症中的潜在作用。还讨论了它们受体的性质及其控制的信号转导事件。最后，介绍了弹性蛋白复合受体的结构选择性，引出了弹性因子（源自弹性蛋白片段化的基质因子）和形态弹性因子的概念，即具有与生物活性弹性蛋白肽相似构象并模拟其作用的肽。
