Barker W C, Andrich M P, Alexander H R, Fraker D L
Nuclear Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Eur J Nucl Med. 1995 Nov;22(11):1242-8. doi: 10.1007/BF00801607.
Regional isolated perfusion using tumor necrosis factor (TNF) shows significant promise for treatment of cancer which is limited to limbs or organs. The high toxicity of TNF requires very sensitive real time monitoring of leakage in order to avoid serious patient complications. Human serum albumin labeled with iodine-131 is used with an externally mounted and collimated NaI(Tl) detector to track the leakage of blood from the isolated perfusion blood circuit into the general systemic vascular space. Blood activity levels measured using the monitor demonstrated a very good correlation with blood serum samples taken concurrently with external monitoring. External monitoring can reduce the risks of perfusion leakage intraoperatively with the precision necessary to safely perform isolated perfusion using TNF.
使用肿瘤坏死因子（TNF）进行区域隔离灌注对于治疗局限于肢体或器官的癌症显示出巨大的前景。TNF的高毒性要求对渗漏进行非常灵敏的实时监测，以避免严重的患者并发症。用碘-131标记的人血清白蛋白与外部安装的准直碘化钠（铊）探测器一起使用，以追踪血液从隔离灌注血液回路漏入全身血管空间的情况。使用该监测器测量的血液活性水平与在外部监测同时采集的血清样本显示出非常好的相关性。外部监测可以在术中降低灌注渗漏的风险，其精度对于安全地使用TNF进行隔离灌注是必要的。
