Kettelhack C, Hohenberger P, Schlag P M
Humboldt-Universität, Virchow-Klinikum, Robert-Rössle-Klinik, Berlin.
Langenbecks Arch Chir Suppl Kongressbd. 1996;113:127-9.
Isolated limb perfusion (ILP) with tumor necrosis factor (TNF) and melphalan was carried out in 21 patients with regionally metastatic malignant melanoma of the limbs. The observed response rate was 65% complete and 15% partial remission. These results warrant further investigation of ILP with TNF and melphalan vs ILP with melphalan alone in a prospective randomised multicenter trial.
对21例肢体局部转移性恶性黑色素瘤患者进行了肿瘤坏死因子（TNF）和美法仑的离体肢体灌注（ILP）治疗。观察到的缓解率为完全缓解65%，部分缓解15%。这些结果值得在前瞻性随机多中心试验中进一步研究TNF和美法仑联合ILP与单纯美法仑ILP的疗效对比。
