Ban Y, Komatsu T, Kemi M, Inagaki S, Nakatsuka T, Matsumoto H
Development Research Laboratories, Banyu Pharmaceutical Co., Ltd. Saitama, Japan.
Exp Anim. 1995 Oct;44(4):315-22. doi: 10.1538/expanim.44.315.
The testes of rats were exposed to a single soft x-ray irradiation at levels of 10, 25 and 63 Gy. Testicular and cauda epididymal weights and their sperm counts were decreased at 7 weeks after the irradiation. Histologically, there was an evidence of interrupted spermatogenesis dose-dependently. Animal mating trails, in which irradiated males were mated with untreated females revealed a slight increase in early stage of postimplantation loss at as low as 10 Gy. There were increases in preimplantation and early stage of postimplantation losses in the group of irradiated at 25 Gy. Infertility occurred in irradiated males at 63 Gy. The effects of irradiation were more severe on the sperm count parameters than on reproductive organ weights, histological examination and reproductive status. The testicular spermatid and epididymal sperm head counts are considered to be useful indicators to detect quantitatively the adverse effects on spermatogenesis.
将大鼠的睾丸暴露于10、25和63 Gy剂量的单次软X射线照射下。照射后7周，睾丸和附睾尾部重量及其精子计数下降。组织学上，有证据表明精子发生中断呈剂量依赖性。在动物交配试验中，将受照射的雄性与未处理的雌性交配，结果显示，低至10 Gy时，植入后早期损失略有增加。25 Gy照射组的植入前和植入后早期损失增加。63 Gy照射的雄性出现不育。照射对精子计数参数的影响比对生殖器官重量、组织学检查和生殖状态的影响更严重。睾丸精子细胞和附睾精子头部计数被认为是定量检测对精子发生不利影响有用的指标。
