Bansal M R, Kaul A, Tewari M, Nehru B
Department of Biophysics, Panjab University, Chandigarh, India.
Reprod Toxicol. 1990;4(4):321-4. doi: 10.1016/0890-6238(90)90044-v.
Quantitative histologic evaluation was performed on the testes of albino rats exposed to scrotal gamma irradiation of 2.5 Gy and 10.0 Gy. The animals were sacrificed at 1, 2, 4, and 16 weeks posttreatment. As a result of irradiation, there was a gradual decrease in testicular weight. The seminiferous tubules of irradiated animals showed arrest of spermatogenesis, desquamation, vacuolization of germinal cells, and multinucleated giant cells. The extent of damage increased with posttreatment interval and with increasing dose. Counting of germinal cells at stage VII of the seminiferous epithelium revealed that the preleptotene spermatocyte is the most sensitive to radiation as compared to other cells. The number of epididymal sperm decreased, whereas the proportion of nonmotile and morphologically abnormal sperm increased following irradiation.
对接受2.5 Gy和10.0 Gy阴囊γ射线照射的白化大鼠睾丸进行了定量组织学评估。在治疗后1、2、4和16周处死动物。照射的结果是睾丸重量逐渐下降。受照射动物的生精小管显示精子发生停滞、生发细胞脱屑、空泡化以及出现多核巨细胞。损伤程度随治疗后时间间隔和剂量增加而加重。对生精上皮VII期的生殖细胞计数显示，与其他细胞相比，前细线期精母细胞对辐射最敏感。照射后附睾精子数量减少，而不动和形态异常精子的比例增加。
