Check J H, Dietterich C, Lurie D
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, USA.
Gynecol Obstet Invest. 1995;40(2):101-7. doi: 10.1159/000292315.
The objective of this prospective comparative study was to investigate the relationship of sonographic measurements of the endometrium at the time of peak follicular maturation to conception outcome in patients treated for luteal phase defects (as determined by out-of-phase endometrial biopsies). Treatments for luteal phase defects included progesterone supplementation with or without follicle-maturing drugs, depending on whether the patient attained a follicle of at least 18 mm and a serum estradiol of > 200 pg/ml. No differences in pregnancy rates were found by the thickness of endometrium (< 10 vs. > or = 10 mm) or echo pattern in any of the treatment modalities. Thus, contrary to findings in stimulated cycles for in vitro fertilization, endometrial thickness at the time of peak follicular maturation is not predictive of outcome in patients treated for luteal phase defects in natural cycles.
这项前瞻性对照研究的目的是，调查在卵泡成熟高峰期时子宫内膜的超声测量值与接受黄体期缺陷治疗患者（根据子宫内膜活检不同步确定）受孕结局之间的关系。黄体期缺陷的治疗方法包括补充黄体酮，是否使用促卵泡成熟药物则取决于患者是否有至少18毫米的卵泡和高于200皮克/毫升的血清雌二醇。在任何治疗方式中，未发现子宫内膜厚度（<10毫米与≥10毫米）或回声模式对妊娠率有差异。因此，与体外受精促排卵周期的研究结果相反，在自然周期中接受黄体期缺陷治疗的患者，卵泡成熟高峰期时的子宫内膜厚度并不能预测结局。
