Vollenhoven B J, Herington A C, Healy D L
Department of Obstetrics and Gynaecology, Monash University, Melbourne, Vic., Australia.
Gynecol Obstet Invest. 1995;40(2):120-4. doi: 10.1159/000292319.
Fibroids (leiomyomata) are the commonest tumours in women, but their aetiology is unknown. Epidermal growth factor (EGF) and transforming growth factor-beta (TGF beta) may be important factors involved in fibroid growth. We examined the mRNA expression of these two growth factors in fibroids and corresponding myometrium from 20 women who underwent hysterectomy because of fibroids. We also examined these factors in samples of fibroids from 9 women who underwent myomectomy after pretreatment with luteinizing hormone-releasing hormone agonists. We found that both factors were expressed in the three types of tissue examined. We also found that there was no difference in the relative abundance of either of the two growth factors between the tissues studied. Despite the lack of difference, we postulate that EGF and TGF beta may be important in fibroid growth because of a possible interaction between the two factors in this tissue.
子宫肌瘤（平滑肌瘤）是女性最常见的肿瘤，但其病因尚不清楚。表皮生长因子（EGF）和转化生长因子-β（TGF-β）可能是参与肌瘤生长的重要因素。我们检测了20例因子宫肌瘤接受子宫切除术的女性的肌瘤及相应子宫肌层中这两种生长因子的mRNA表达。我们还检测了9例在接受促黄体生成素释放激素激动剂预处理后接受肌瘤切除术的女性的肌瘤样本中的这些因子。我们发现这两种因子在所检测的三种组织类型中均有表达。我们还发现，在所研究的组织之间，这两种生长因子中任何一种的相对丰度均无差异。尽管没有差异，但我们推测EGF和TGF-β在肌瘤生长中可能很重要，因为这两种因子在该组织中可能存在相互作用。
