Davies R L, Yoon S J, Weissenbach J, Ward D, Krauter K, Kucherlapati R
Department of Biology, Sweet Briar College, Virginia 24595, USA.
Genomics. 1995 Oct 10;29(3):766-8. doi: 10.1006/geno.1995.9939.
ELA1, the pancreatic elastase 1 gene, is conserved in mammalian genomes. ELA1 was previously mapped to chromosome 12 using a panel of mouse-human somatic cell hybrids. We now report the physical and cytogenetic localization of the ELA1 gene. On the physical map, ELA1 is adjacent to the polymorphic marker AFMa283yg1 and between D12S361 and D12S347. Using fluorescence in situ hybridization, we determined that ELA1 maps to 12q13.
ELA1，即胰腺弹性蛋白酶1基因，在哺乳动物基因组中是保守的。ELA1基因先前通过一组小鼠 - 人类体细胞杂种被定位到12号染色体上。我们现在报告ELA1基因的物理定位和细胞遗传学定位。在物理图谱上，ELA1与多态性标记AFMa283yg1相邻，位于D12S361和D12S347之间。利用荧光原位杂交技术，我们确定ELA1定位于12q13。
