Georgatos S D, Maison C
Program of Cell Biology, European Molecular Biology Laboratory, Germany.
Int Rev Cytol. 1996;164:91-138. doi: 10.1016/s0074-7696(08)62385-2.
The intermediate filaments represent core components of the cytoskeleton and are known to interact with several membranous organelles. Classic examples of this are the attachment of keratin filaments to the desmosomes and the association of the lamin filament meshwork with the inner nuclear membrane. At this point, the molecular mechanisms by which the filaments link to membranes are not clearly understood. However, since a substantial body of information has been amassed, the time is now ripe for comparing notes and formulating working hypotheses. With this objective in mind, we review here pioneering studies on this subject, together with work that has appeared more recently in the literature.
中间丝是细胞骨架的核心组成部分，已知其与多种膜性细胞器相互作用。典型的例子是角蛋白丝与桥粒的附着以及核纤层丝网络与内核膜的关联。目前，对于丝与膜相连的分子机制尚不清楚。然而，由于已经积累了大量信息，现在是交流心得并形成可行假设的时候了。出于这一目的，我们在此回顾关于该主题的开创性研究以及近期文献中出现的相关工作。
