Weiersmüller A, Colombo J P, Bircher J
Am J Dig Dis. 1977 May;22(5):424-8. doi: 10.1007/BF01071890.
In view of the importance of liver tests in the follow-up of patients under treatment with corticosteroid hormones, 20 mg of prednisolone were given by mouth to normal volunteers for 4 days and hepatic function was assessed before and during treatment. Despite significant falls in plasma cortisol and serum bilirubin concentrations, the galactose elimination capacity, the BSP tests, and the urinary D-glucaric acid output remained essentially unchanged. Consequently no pharmacological effect of this corticosteroid hormone on the examined tests could be detected.
鉴于肝脏检测在接受皮质类固醇激素治疗患者随访中的重要性，对正常志愿者口服20毫克泼尼松龙，持续4天，并在治疗前和治疗期间评估肝功能。尽管血浆皮质醇和血清胆红素浓度显著下降，但半乳糖清除能力、BSP试验和尿D-葡萄糖醛酸排出量基本保持不变。因此，未检测到这种皮质类固醇激素对所检查检测项目的药理作用。
