Rigg L A, Yen S S
Am J Obstet Gynecol. 1977 May 15;128(2):215-8. doi: 10.1016/0002-9378(77)90692-5.
Prolactin (PRL) secretion in the periparturitional period in patients undergoing labor and vaginal delivery follows a remarkable multiphasic pattern not found in patients who underwent elective cesarean section without labor. There is a highly significant decline in PRL levels during active labor which reaches a nadir about two hours prior to delivery. Immediately after delivery, a surge of PRL is noted, reaching peak levels within two hours post partum. Thereafter, PRL levels fall, reaching a second nadir about nine hours post partum, and this low level is maintained for nine to 24 hours after delivery. This multiphasic pattern of PRL secretion is not correlated with changes in serum concentrations of cortisol, progesterone, estradiol, or estrone. PRL levels in all pregnant patients at term were unaffected by the administration of synthetic narcotic analgesic agents, anesthesia, or the stress of operation. It is concluded that PRL secretion in the pregnant patient at term is unresponsive to usual stimuli and that the multiphasic pattern of PRL secretion uniquely found with labor and vaginal delivery may be associated with dopaminergic neuroendocrine processes during human parturition.
在经历自然分娩和阴道分娩的患者围产期，催乳素（PRL）分泌呈现出一种显著的多相模式，而在未经历分娩的择期剖宫产患者中未发现这种模式。在活跃分娩期间，PRL水平显著下降，在分娩前约两小时降至最低点。分娩后立即出现PRL激增，在产后两小时内达到峰值水平。此后，PRL水平下降，在产后约九小时达到第二个最低点，并且在分娩后九至二十四小时维持在低水平。PRL分泌的这种多相模式与皮质醇、孕酮、雌二醇或雌酮的血清浓度变化无关。足月妊娠患者的PRL水平不受合成麻醉性镇痛药、麻醉或手术应激的影响。得出的结论是，足月妊娠患者的PRL分泌对通常的刺激无反应，并且在自然分娩和阴道分娩中独特发现的PRL分泌多相模式可能与人类分娩期间的多巴胺能神经内分泌过程有关。
