Barth L, Dannhorn R
Anaesthesist. 1977 Mar;26(3):116-24.
Spontaneous decurarization after single doses of tubocurarine (d-Tc) 0.44+/-0.04 mg/kg, pancuronium (PANC) 0.093+/-0.013 mg/kg, gallamine (GALL) 1.69+/-0.31 mg/kg and alcuronium (ALC) 0.193+/-0.02 mg/kg b.w. was investigated by means of tetanic stimulation of the ulnar nerve in 37 routinely anaesthesized adults of either sex. Tetani of 4-5 s and 30-400 Hz were sustained prior to muscle relaxation during light anaesthesia. After the injection of muscle relaxants the frequency of incomplete myographic black-out revealed slight underestimation of the doses of both GALL and ALC. However, no significant differences could be found between the drugs investigated, as far as latency of recovery is concerned. Recovery time to 30 Hz (=75-80% receptor occlusion) was 110+/-37, 109+/-66, 92+/-25 and 90+/-35 minutes for d-Tc, GALL, PANC and ALC, respectively. Up to 100 Hz (=50% receptor occlusion) it was 328+/-69, 327+/-83, 282+/-88 and 218+/-66 minutes for d-Tc, ALC, GALL and PANC, respectively. Myographic recurarization rather frequently occurred with ALC, GALL and d-Tc. The use of antidotes seems urgently to be indicated whenever non-depolarizing muscle relaxants have been applied in the above mentioned range of dosage.
通过对37例常规麻醉的成年男女的尺神经进行强直刺激，研究了单次静脉注射筒箭毒碱（d-Tc）0.44±0.04mg/kg、泮库溴铵（PANC）0.093±0.013mg/kg、加拉碘铵（GALL）1.69±0.31mg/kg和阿库氯铵（ALC）0.193±0.02mg/kg体重后出现的自发去极化现象。在浅麻醉下肌肉松弛前，持续进行4 - 5秒、频率为30 - 400Hz的强直刺激。注射肌肉松弛剂后，不完全肌电图消失的频率显示GALL和ALC的剂量略有低估。然而，就恢复潜伏期而言，所研究的药物之间未发现显著差异。恢复到30Hz（=75 - 80%受体阻断）的时间，d-Tc、GALL、PANC和ALC分别为110±37、109±66、92±25和90±35分钟。恢复到100Hz（=50%受体阻断）的时间，d-Tc、ALC、GALL和PANC分别为328±69、327±83、282±88和218±66分钟。使用ALC、GALL和d-Tc时，肌电图复极化相当频繁地发生。只要在上述剂量范围内使用非去极化肌肉松弛剂，似乎就迫切需要使用解毒剂。
