Smirnova O A
Kosm Biol Aviakosm Med. 1991 Sep-Oct;25(5):53-6.
The mathematical model of the dynamics of humoral immune responses to soluble antigens has been developed. This is a system of nonlinear differential equations describing concentrations of immunocompetent B-lymphocytes, plasma cells, antibodies and antigen. The model reproduces cyclic kinetics of the immune reaction to slowly catabolizing antigens which is observed experimentally. Within the framework of the model a description of the mechanism of origin of oscillatory modes of the dynamics of the immune response is presented. It has been shown that the feedback in the control of the antibody synthesis by antibodies is due to neutralization of the main stimulus of the immune system, i.e., free molecules of the antigen--by circulating antibodies.
已建立了针对可溶性抗原的体液免疫反应动力学的数学模型。这是一个非线性微分方程组，描述了免疫活性B淋巴细胞、浆细胞、抗体和抗原的浓度。该模型再现了实验中观察到的对缓慢分解代谢抗原的免疫反应的周期性动力学。在该模型的框架内，对免疫反应动力学振荡模式的起源机制进行了描述。结果表明，抗体对抗体合成控制中的反馈是由于免疫系统的主要刺激物，即游离的抗原分子，被循环抗体中和所致。
