Tripple M, Shadomy S, Espinel-Ingroff A
Am Rev Respir Dis. 1977 May;115(5):879-81. doi: 10.1164/arrd.1977.115.5.879.
The availability of active amphotericin B after filtration of the intravenous form of the drug through in-line filters was examined. Filtration through circular filters of 25-mm diameter and 0.45-micronm pore size resulted in little loss of active drug, although a marked decrease in flow occurred with time. Filtration through either circular or cylindrical filters with 0.22-micronm pores resulted both in significant losses of active drug and in marked decreases in flow. Thus, membrane filters of 0.22-micronm pore size are not suitable for use in intravenous administration of amphotericin B. The use of filters of 0.45-micronm pore size is appropriate only in situations in which decreased flow is acceptable.
研究了两性霉素B静脉制剂经在线过滤器过滤后活性药物的可得性。通过直径25毫米、孔径0.45微米的圆形过滤器过滤，活性药物损失很少，尽管随着时间推移流量显著下降。通过孔径0.22微米的圆形或圆柱形过滤器过滤，活性药物均有显著损失，且流量明显下降。因此，孔径0.22微米的膜过滤器不适用于两性霉素B的静脉给药。仅在流量降低可接受的情况下，使用孔径0.45微米的过滤器才是合适的。
