Rapp R P, Bivins B A, DeLuca P
Am J Hosp Pharm. 1979 Dec;36(12):1711-3.
The effects of three final filter pore sizes on sepsis and survival times in rabbits infused with contaiminated intravenous fluids were compared. Intravenous fluids were administered for up to 12 hours to five groups of rabbits. Groups 2, 3 and 4 received fluids, contaminated with Gram-negative rods, that were filtered with 0.22-, 1.0- and 5.0-micrometers filters, respectively. Rabbits in Groups 1 and 5 received uncontaminated and contaminated fluids, respectively, neither of which was filtered. Cultures were taken of blood and of fluid below the filters, and rabbit survival times were recorded. At 6, 8 and 12 hours, Group 2 survival time was not significantly different from that of the negative control; the survival times for Groups 3, 4 and 5 were significantly less than for the negative control. Fluid and blood cultures of Group 2 were negative or statistically indistinguishable from those of Group 1. Cultures for Groups 3, 4 and 5 were positive. The study suggests that 1.0- and 5.0-micrometers inline final filters have no beneficial effect on survival following infusion of contaminated fluids, but that 0.22-micrometer inline final filters increase survival time.
比较了三种最终过滤器孔径对输注受污染静脉输液的兔子败血症及存活时间的影响。对五组兔子静脉输液长达12小时。第2、3和4组分别接受被革兰氏阴性杆菌污染且经0.22微米、1.0微米和5.0微米过滤器过滤的液体。第1组和第5组兔子分别接受未受污染和受污染的液体，二者均未经过滤。采集血液和过滤器下方液体的样本进行培养，并记录兔子的存活时间。在6小时、8小时和12小时时，第2组的存活时间与阴性对照组无显著差异；第3、4和5组的存活时间显著短于阴性对照组。第2组的液体和血液培养结果为阴性，或与第1组在统计学上无差异。第3、4和5组的培养结果为阳性。该研究表明，1.0微米和5.0微米的在线最终过滤器对输注受污染液体后的存活没有有益影响，但0.22微米的在线最终过滤器可延长存活时间。
