阿尔茨海默病之谜及其褪黑素预防方法
The mystery of Alzheimer's disease and its prevention by melatonin.
作者信息
Maurizi C P
机构信息
Department of Pathology, Houston Medical Center, Warner Robins, Georgia 31093, USA.
出版信息
Med Hypotheses. 1995 Oct;45(4):339-40. doi: 10.1016/0306-9877(95)90092-6.
PMID:8577295
Abstract
Preliminary observation suggested that a melatonin deficiency could cause Alzheimer's disease. New evidence reveals that: 1) a significant melatonin deficiency is common in the disease, 2) melatonin acts as a hydroxyl radical scavenger and 3) brain tissue mitochondria from Alzheimer's patients have damage consistent with hydroxyl radical injury.
摘要
初步观察表明褪黑素缺乏可能导致阿尔茨海默病。新证据显示：1）该病中显著的褪黑素缺乏很常见，2）褪黑素可作为羟基自由基清除剂，3）阿尔茨海默病患者的脑组织线粒体存在与羟基自由基损伤相符的损害。
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