Maurizi C P
Department of Pathology, Houston Medical Center, Warner Robins, Georgia 31093, USA.
Med Hypotheses. 1995 Oct;45(4):339-40. doi: 10.1016/0306-9877(95)90092-6.
Preliminary observation suggested that a melatonin deficiency could cause Alzheimer's disease. New evidence reveals that: 1) a significant melatonin deficiency is common in the disease, 2) melatonin acts as a hydroxyl radical scavenger and 3) brain tissue mitochondria from Alzheimer's patients have damage consistent with hydroxyl radical injury.
初步观察表明褪黑素缺乏可能导致阿尔茨海默病。新证据显示：1）该病中显著的褪黑素缺乏很常见，2）褪黑素可作为羟基自由基清除剂，3）阿尔茨海默病患者的脑组织线粒体存在与羟基自由基损伤相符的损害。
