Baltatu Ovidiu C, Amaral Fernanda G, Campos Luciana A, Cipolla-Neto Jose
Center of Innovation, Technology and Education (CITE) at Anhembi Morumbi University-Laureate International Universities, 500 Dr. Altino Bondensan Ave, São José dos Campos, SP, 12247-016, Brazil.
Department of Physiology, Federal University of São Paulo, 862 Botucatu St, 5th Floor, São Paulo, SP, 04023-901, Brazil.
Cell Mol Life Sci. 2017 Nov;74(21):3955-3964. doi: 10.1007/s00018-017-2613-y. Epub 2017 Aug 8.
Melatonin, due to its multiple means and mechanisms of action, plays a fundamental role in the regulation of the organismal physiology by fine tunning several functions. The cardiovascular system is an important site of action as melatonin regulates blood pressure both by central and peripheral interventions, in addition to its relation with the renin-angiotensin system. Besides, the systemic management of several processes, melatonin acts on mitochondria regulation to maintain a healthy cardiovascular system. Hypertension affects target organs in different ways and cellular energy metabolism is frequently involved due to mitochondrial alterations that include a rise in reactive oxygen species production and an ATP synthesis decrease. The discussion that follows shows the role played by melatonin in the regulation of mitochondrial physiology in several levels of the cardiovascular system, including brain, heart, kidney, blood vessels and, particularly, regulating the renin-angiotensin system. This discussion shows the putative importance of using melatonin as a therapeutic tool involving its antioxidant potential and its action on mitochondrial physiology in the cardiovascular system.
褪黑素因其多种作用方式和机制，通过微调多种功能在机体生理调节中发挥着重要作用。心血管系统是褪黑素的一个重要作用部位，因为褪黑素除了与肾素 - 血管紧张素系统有关外，还通过中枢和外周干预来调节血压。此外，除了对多个过程的系统性管理外，褪黑素还作用于线粒体调节以维持健康的心血管系统。高血压以不同方式影响靶器官，由于线粒体改变，包括活性氧产生增加和ATP合成减少，细胞能量代谢经常受到影响。接下来的讨论展示了褪黑素在心血管系统多个层面（包括脑、心脏、肾脏、血管，特别是调节肾素 - 血管紧张素系统）的线粒体生理调节中所起的作用。该讨论表明了利用褪黑素作为治疗工具的潜在重要性，这涉及到其抗氧化潜力及其在心血管系统中线粒体生理方面的作用。
