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恒河猴前额叶皮质向基底脑桥的投射:小脑对高级功能贡献的意义。

Prefrontal cortex projections to the basilar pons in rhesus monkey: implications for the cerebellar contribution to higher function.

作者信息

Schmahmann J D, Pandya D N

机构信息

Department of Neurology, Massachusetts General Hospital, Boston 02114, USA.

出版信息

Neurosci Lett. 1995 Oct 27;199(3):175-8. doi: 10.1016/0304-3940(95)12056-a.

DOI:10.1016/0304-3940(95)12056-a
PMID:8577391
Abstract

The feedforward limb of the cerebrocerebellar system is directed largely through the corticopontine pathway. We determined the extent to which higher order corticopontine projections are derived from prefrontal associative cortices by injecting anterograde tracers into multiple prefrontal regions in rhesus monkeys. Most prefrontopontine projections were derived from the dorsolateral and dorsomedial convexities, including areas 8A, 46 dorsal, 9, and 10; and lighter projections arose from medial and ventrolateral cortices. These findings strengthen the observation that the cerebrocerebellar system incorporates associative cerebral regions, and they enhance the notion that the cerebellum participates in the organization of cognitive function.

摘要

大脑小脑系统的前馈分支主要通过皮质脑桥通路传导。我们通过向恒河猴的多个前额叶区域注射顺行示踪剂,确定了高阶皮质脑桥投射源自前额叶联合皮质的程度。大多数前额叶脑桥投射源自背外侧和背内侧凸面,包括8A区、46区背侧、9区和10区;而内侧和腹外侧皮质的投射则较稀疏。这些发现强化了大脑小脑系统包含联合脑区的观察结果,并进一步支持了小脑参与认知功能组织的观点。

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