Obara H, Ikoma N, Sasaki K, Tachi K
Department of Ophthalmology, Kanazawa Medical University, Uchinada, Japan.
Ophthalmic Res. 1995;27 Suppl 1:100-3. doi: 10.1159/000267853.
A 24-year old female with ocular changes (Kayser-Fleischer ring and sunflower cataract) indicating Wilson's disease was followed up from 9 years of age with anterior eye segment image documentation by Scheimpflug photography. A low copper diet and systemic D-penicillamine were administered after the initial diagnosis of Wilson's disease. During a 15-year follow-up period, the yellowish/brown-colored granular opacification on the anterior lens capsule and/or in the capsule has mostly disappeared and instead, the same type of opacification has emerged on the posterior lens capsule, showing rather progressive changes compared with the initial findings. These changes which had developed in the lens during the past 15 years were difficult to detect by slit lamp examination alone, but they were clearly revealed by Scheimpflug slit images. To our knowledge this is the first case report on ocular changes disclosed through the application of a newly developed anterior eye segment examination. Ergo, Scheimpflug photography is valuable for follow-up studies of ocular complications seen in patients with Wilson's disease.
一名24岁患有眼部病变（凯-弗环和向日葵样白内障）提示肝豆状核变性的女性患者，从9岁起就通过Scheimpflug摄影对眼前节进行图像记录。在初步诊断为肝豆状核变性后，给予低铜饮食和全身性D-青霉胺治疗。在15年的随访期内，晶状体前囊膜上和/或囊内的黄棕色颗粒状混浊大多消失，取而代之的是，相同类型的混浊出现在晶状体后囊膜上，与最初的发现相比呈现出相当进展性的变化。过去15年中晶状体发生的这些变化仅通过裂隙灯检查很难发现，但Scheimpflug裂隙图像能清楚地显示出来。据我们所知，这是首例通过应用新开发的眼前节检查所揭示的眼部变化的病例报告。因此，Scheimpflug摄影对于肝豆状核变性患者眼部并发症的随访研究具有重要价值。
