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Chemical and biological properties of cytotoxic alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones.

作者信息

Liu M C, Lin T S, Sartorelli A C

机构信息

Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.

出版信息

Prog Med Chem. 1995;32:1-35. doi: 10.1016/s0079-6468(08)70451-x.

DOI:10.1016/s0079-6468(08)70451-x
PMID:8577916
Abstract
摘要

相似文献

1
Chemical and biological properties of cytotoxic alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones.细胞毒性α-（N）-杂环羧醛缩氨基硫脲的化学和生物学性质
Prog Med Chem. 1995;32:1-35. doi: 10.1016/s0079-6468(08)70451-x.
2
Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo.一系列新型吡啶-2-甲醛硫代半卡巴腙对核糖核苷酸还原酶活性以及培养中和体内肿瘤细胞生长的结构-功能关系
Adv Enzyme Regul. 1995;35:55-68. doi: 10.1016/0065-2571(94)00005-n.
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Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.吡啶-2-甲醛缩氨基硫脲的3-氨基和5-氨基衍生物的合成及生物活性
J Med Chem. 1996 Jun 21;39(13):2586-93. doi: 10.1021/jm9600454.
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Potential antitumor agents. 10. Synthesis and biochemical properties of 5-N-alkylamino-,N,N-dialkylamino-, and N-alkylacetamido-1-formylisoquinoline thiosemicarbazones.潜在的抗肿瘤剂。10. 5-N-烷基氨基、N,N-二烷基氨基和N-烷基乙酰氨基-1-甲酰基异喹啉硫代半卡巴腙的合成及生化性质
J Med Chem. 1974 Nov;17(11):1145-50. doi: 10.1021/jm00257a004.
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Synthesis and antitumor activity of 3- and 5-hydroxy-4-methylpyridine-2-carboxaldehyde thiosemicarbazones.3-和5-羟基-4-甲基吡啶-2-甲醛缩氨基硫脲的合成及其抗肿瘤活性
J Med Chem. 1992 Oct 2;35(20):3667-71. doi: 10.1021/jm00098a011.
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4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone, a second-generation antineoplastic agent of the alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazone series.4-甲基-5-氨基-1-甲酰基异喹啉硫代半卡巴腙，α-(N)-杂环羧醛硫代半卡巴腙系列的第二代抗肿瘤剂。
Cancer Res. 1977 Jun;37(6):1692-6.
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Potential antitumor agents. 11. Inhibitors of alkaline phosphatase, an enzyme involved in the resistance of neoplastic cells to 6-thiopurines.潜在的抗肿瘤药物。11. 碱性磷酸酶抑制剂，一种与肿瘤细胞对6-硫代嘌呤耐药性有关的酶。
J Med Chem. 1974 Sep;17(9):934-8. doi: 10.1021/jm00255a005.
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Characterization of the biochemical mechanism of action of alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones.
Adv Enzyme Regul. 1976;15:117-39. doi: 10.1016/0065-2571(77)90012-7.
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Alpha-(N)-formylheteroaromatic thiosemicarbazones. Inhibition of tumor-derived ribonucleoside diphosphate reductase and correlation with in vivo antitumor activity.α-（N）-甲酰基杂芳基硫代半卡巴腙。对肿瘤来源的核糖核苷二磷酸还原酶的抑制作用及其与体内抗肿瘤活性的相关性。
J Med Chem. 1974 Feb;17(2):172-81. doi: 10.1021/jm00248a006.
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Potential antitumor agents. 5. Methylated -(N)-heterocyclic carboxaldehyde thiosemicarbazones.潜在的抗肿瘤剂。5. 甲基化的-(N)-杂环羧醛缩氨基硫脲。
J Med Chem. 1972 Feb;15(2):192-5. doi: 10.1021/jm00272a016.

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