Williams S A, Suen Y, Cairo M S
Division of Hematology/Oncology and Blood and Bone Marrow Transplantation, Children's Hospital of Orange County, CA 92668, USA.
Semin Diagn Pathol. 1995 Nov;12(4):335-41.
Molecular analysis, combined with cytogenetic studies of proto-oncogenes and tumor suppressor genes, has provided insight into the pathogenesis of non-Hodgkin's lymphoma. Characterization of these malignancies at the molecular level will aid in developing more sensitive detection methods for earlier and more accurate diagnosis. Thus, genetic rearrangements provide highly specific molecular markers for monitoring malignant cells. Additionally, a more detailed understanding of the precise, molecular steps leading to malignant transformation will facilitate the development of more specific and, perhaps, less toxic therapies.
分子分析与原癌基因和肿瘤抑制基因的细胞遗传学研究相结合，为非霍奇金淋巴瘤的发病机制提供了深入了解。在分子水平上对这些恶性肿瘤进行特征描述将有助于开发更灵敏的检测方法，以实现更早、更准确的诊断。因此，基因重排为监测恶性细胞提供了高度特异性的分子标记。此外，对导致恶性转化的确切分子步骤有更详细的了解，将有助于开发更具特异性、或许毒性更小的治疗方法。
