Kiefel V, Vicariot M, Breitfeld C, Giptner A, Schlüter C, Böhringer M, Santoso S, Kroll H, Mueller-Eckhardt C
Institut für Klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität Giessen, Deutschland.
Beitr Infusionsther Transfusionsmed. 1994;32:247-9.
Neonatal alloimmune thrombocytopenia is the consequence of maternal alloimmunization against platelet-specific alloantigens, usually PIA1 or Br(a). The clinical picture is characterized by signs of haemorrhagic diathesis as a result of marked thrombocytopenia. In the last years, rare cases of immunization against 'low-frequency' or 'private' platelet alloantigens on the platelet glycoprotein (GP) complex IIb/IIIa have been found. This is the first report on NAIT due to maternal immunization against a low-frequency platelet alloantigen ('Iy') localized on platelet GP Ib/IX.
新生儿同种免疫性血小板减少症是母体针对血小板特异性同种抗原（通常为PIA1或Br(a)）发生同种免疫的结果。临床表现为因显著血小板减少而出现的出血素质体征。在过去几年中，已发现罕见的针对血小板糖蛋白（GP）复合物IIb/IIIa上“低频”或“私有”血小板同种抗原发生免疫的病例。这是关于因母体针对定位于血小板GP Ib/IX上的低频血小板同种抗原（“Iy”）发生免疫而导致的新生儿同种免疫性血小板减少症的首例报告。
