[针对血小板糖蛋白Ib/IX上一种新的、罕见同种异体抗原（Iy）进行免疫接种，作为新生儿同种免疫性血小板减少症严重病例的病因]

[Immunization against a new, infrequent alloantigen (Iy) on the platelet glycoprotein Ib/IX as a cause of a serious case of neonatal alloimmune thrombocytopenia].

作者信息

Kiefel V, Vicariot M, Breitfeld C, Giptner A, Schlüter C, Böhringer M, Santoso S, Kroll H, Mueller-Eckhardt C

机构信息

Institut für Klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität Giessen, Deutschland.

出版信息

Beitr Infusionsther Transfusionsmed. 1994;32:247-9.

Abstract

Neonatal alloimmune thrombocytopenia is the consequence of maternal alloimmunization against platelet-specific alloantigens, usually PIA1 or Br(a). The clinical picture is characterized by signs of haemorrhagic diathesis as a result of marked thrombocytopenia. In the last years, rare cases of immunization against 'low-frequency' or 'private' platelet alloantigens on the platelet glycoprotein (GP) complex IIb/IIIa have been found. This is the first report on NAIT due to maternal immunization against a low-frequency platelet alloantigen ('Iy') localized on platelet GP Ib/IX.

摘要

新生儿同种免疫性血小板减少症是母体针对血小板特异性同种抗原（通常为PIA1或Br(a)）发生同种免疫的结果。临床表现为因显著血小板减少而出现的出血素质体征。在过去几年中，已发现罕见的针对血小板糖蛋白（GP）复合物IIb/IIIa上“低频”或“私有”血小板同种抗原发生免疫的病例。这是关于因母体针对定位于血小板GP Ib/IX上的低频血小板同种抗原（“Iy”）发生免疫而导致的新生儿同种免疫性血小板减少症的首例报告。

相似文献

1

[Immunization against a new, infrequent alloantigen (Iy) on the platelet glycoprotein Ib/IX as a cause of a serious case of neonatal alloimmune thrombocytopenia].[针对血小板糖蛋白Ib/IX上一种新的、罕见同种异体抗原（Iy）进行免疫接种，作为新生儿同种免疫性血小板减少症严重病例的病因]

Beitr Infusionsther Transfusionsmed. 1994;32:247-9.

2

[Anti Ko(a) as a cause of neonatal alloimmune thrombocytopenia].

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3

Alloimmunization against Iy, a low-frequency antigen on platelet glycoprotein Ib/IX as a cause of severe neonatal alloimmune thrombocytopenic purpura.针对血小板糖蛋白Ib/IX上的低频抗原Iy的同种免疫，是严重新生儿同种免疫性血小板减少性紫癜的一个病因。

Vox Sang. 1995;69(3):250-4. doi: 10.1111/j.1423-0410.1995.tb02604.x.

4

Immunization against a low-frequency human platelet alloantigen in fetal alloimmune thrombocytopenia is not a single event: characterization by the combined use of reference DNA and novel allele-specific cell lines expressing recombinant antigens.胎儿同种免疫性血小板减少症中针对低频人类血小板同种抗原的免疫接种并非单一事件：通过联合使用参考DNA和表达重组抗原的新型等位基因特异性细胞系进行表征。

Transfusion. 2005 Mar;45(3):353-8. doi: 10.1111/j.1537-2995.2005.04218.x.

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[Sr(a), a "private" thrombocyte alloantigen as a cause of neonatal alloimmune thrombocytopenia].[锶（a），一种“私人”血小板同种抗原作为新生儿同种免疫性血小板减少症的病因]

Beitr Infusionsther. 1990;26:389-91.

6

Frequencies of maternal platelet alloantibodies and autoantibodies in suspected fetal/neonatal alloimmune thrombocytopenia, with emphasis on human platelet antigen-15 alloimmunization.疑似胎儿/新生儿同种免疫性血小板减少症中母体血小板同种抗体和自身抗体的频率，重点关注人类血小板抗原-15同种免疫

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7

Low prevalence of a polymorphism of platelet membrane glycoprotein Ib beta associated with neonatal alloimmune thrombocytopenic purpura in Asian populations.

Int J Hematol. 1999 Jan;69(1):54-6.

8

[Neonatal isoimmune thrombocytopenia by anti-GP IIb/IIIa].[抗糖蛋白IIb/IIIa所致新生儿同种免疫性血小板减少症]

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[Severe neonatal alloimmune thrombocytopenia with delayed antibody detection].[伴有延迟抗体检测的严重新生儿同种免疫性血小板减少症]

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Single amino acid substitution in human platelet glycoprotein Ibbeta is responsible for the formation of the platelet-specific alloantigen Iy(a).人类血小板糖蛋白Ibbeta中的单个氨基酸取代导致了血小板特异性同种抗原Iy(a)的形成。

Blood. 2000 Mar 1;95(5):1849-55.

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