Lajos S, Katalin R, László T, Miklós M, István K, László R
Institute of Pathophysiology, Semmelweis University Medical School, Budapest, Hungary.
Acta Biomed Ateneo Parmense. 1995;66(3-4):153-9.
The intact triacylglycerol profiles for VLDL and LDL of healthy and primary hypertriglyceridemic patients were obtained by high temperature capillary gas chromatography. The data were treated by the methods of computerized analysis. Marked individual heterogeneity was found. This can be explained by either genetic polymorphism or multiple lipoprotein triacylglycerol pools within one density class. Suspecting genetic polymorphism and determination type IV (familial hypertriglyceridemia) seems to be a pure overproduction of endogenous VLDL, while in type II B (familial combined hyperlipidemia) an altered mechanism of triacyglycerol synthesis can be supposed.
通过高温毛细管气相色谱法获得了健康人和原发性高甘油三酯血症患者极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）完整的甘油三酯谱。数据采用计算机分析方法处理。发现了明显的个体异质性。这可以通过基因多态性或一个密度类内的多个脂蛋白甘油三酯池来解释。怀疑基因多态性并确定IV型（家族性高甘油三酯血症）似乎是内源性VLDL的单纯过度产生，而在II B型（家族性混合性高脂血症）中，可以推测甘油三酯合成机制发生了改变。
