Reid C B, Fagan P A, Turner J
St Vincent's Hospital, Sydney, New South Wales, Australia.
Am J Otol. 1994 May;15(3):419-22.
Skull base chondrosarcoma and chordoma are rare tumors that generally have a poor prognosis. In 1973, Heffelfinger et al described a chondroid variant of chordoma, called chondroid chordoma that was found to have a significantly better prognosis than classic chordoma. However, recent evidence suggests that many of the tumors diagnosed as chondroid chordoma may, in fact, be low-grade myxoid chondrosarcomas. This report presents the diagnosis and treatment of two cases of skull base tumor that were diagnosed preoperatively as schwannoma because they were thought initially to be centred on the jugular foramen. Initial histologic evaluation suggested chondroid chordoma, but immunohistologic techniques and a review of the literature led to a diagnosis of low-grade myxoid chondrosarcoma.
颅底软骨肉瘤和脊索瘤是罕见肿瘤，通常预后较差。1973年，赫费尔芬格等人描述了一种脊索瘤的软骨样变体，称为软骨样脊索瘤，发现其预后明显优于经典脊索瘤。然而，最近的证据表明，许多被诊断为软骨样脊索瘤的肿瘤实际上可能是低级别黏液样软骨肉瘤。本报告介绍了两例颅底肿瘤的诊断和治疗情况，这两例肿瘤术前被诊断为神经鞘瘤，因为最初认为它们以颈静脉孔为中心。最初的组织学评估提示为软骨样脊索瘤，但免疫组织学技术和文献回顾导致诊断为低级别黏液样软骨肉瘤。
