Gautier C, Husson A, Vaillant R
Biochimie. 1977;59(1):91-5. doi: 10.1016/s0300-9084(77)80091-6.
The five urea cycle enzyme activities of rat liver are followed during late fetal period and the first day of life. All five enzymes exhibit relatively low activities in foetal liver and a rapid postnatal increase. Lack of glucocorticosteroid (after hypophysectomy in utero) induces an important decrease of activity of three enzymes: carbamyl phosphate synthetase, ornithine transcarbamylase and argininosuccinate synthetase. Treatment with hydrocortisone acetate on decapitated fetuses results in a marked stimulation of the activity of four of the enzymes: carbamyl phosphate synthetase, ornithine transcarbamylase, argininosuccinate synthetase and arginase. Premature induction of carbamyl phosphate synthetase activity is obtained after intraperitoneal injection with hydrocortisone acetate at 16,5 days of gestation.
在胎儿后期和出生后的第一天，对大鼠肝脏的五种尿素循环酶活性进行了跟踪研究。所有这五种酶在胎儿肝脏中的活性相对较低，出生后迅速增加。缺乏糖皮质激素（子宫内垂体切除术后）会导致三种酶的活性显著降低：氨甲酰磷酸合成酶、鸟氨酸转氨甲酰酶和精氨琥珀酸合成酶。对断头胎儿用醋酸氢化可的松治疗会导致四种酶的活性显著增强：氨甲酰磷酸合成酶、鸟氨酸转氨甲酰酶、精氨琥珀酸合成酶和精氨酸酶。在妊娠16.5天时腹腔注射醋酸氢化可的松后，可提前诱导氨甲酰磷酸合成酶的活性。
