Revskoĭ A Iu, Kalashnikov S A, Arkhipov V F
Arkh Patol. 1995 Sep-Oct;57(5):42-6.
Insulinoma diagnosis may be sometimes very difficult. Insulinomas and extra-tumor pancreatic tissue from 31 patients underwent combined macro- and microscopical investigation in order to find morphological changes important for the diagnosis. The silver impregnation of pancreatic islands according to Grimelius appeared to be most informative. Negative reaction in Langerhans islands shows the presence of insulinoma; positive Grimelius reaction makes the diagnosis of insulinoma doubtful.
胰岛素瘤的诊断有时可能非常困难。对31例患者的胰岛素瘤及肿瘤外胰腺组织进行了大体和显微镜联合检查，以寻找对诊断有重要意义的形态学改变。根据格里梅利乌斯法对胰岛进行银浸染似乎最具信息量。朗格汉斯岛的阴性反应表明存在胰岛素瘤；格里梅利乌斯阳性反应则使胰岛素瘤的诊断存疑。
