Chariot P, Gherardi R
Groupe de Recherche en Pathologie Neuromusculaire, Hôpital Henri Mondor, Créteil, France.
Curr Opin Rheumatol. 1995 Nov;7(6):497-502. doi: 10.1097/00002281-199511000-00006.
Skeletal muscle involvement may occur at all stages of HIV infection. The most simple classification of muscular disorders in HIV-infected patients is 1) HIV-associated myopathies, 2) zidovudine myopathy, 3) HIV wasting syndrome, and 4) opportunistic infections and tumoral infiltrations of muscle. Immunohistology for major histocompatibility complex class I antigen and histochemical reaction for cytochrome c oxidase are helpful in correctly classifying a myopathy as HIV polymyositis or zidovudine myopathy. Studies of cytokine expression in HIV-infected patients and of supplementation with compounds such as carnitine or micronutrients such as selenium might yield new insights into the pathogenesis and treatment of the various AIDS-associated muscular disorders.
骨骼肌受累可能发生在HIV感染的各个阶段。HIV感染患者肌肉疾病最简单的分类是：1）HIV相关性肌病；2）齐多夫定肌病；3）HIV消耗综合征；4）肌肉的机会性感染和肿瘤浸润。主要组织相容性复合体I类抗原的免疫组织化学检查和细胞色素c氧化酶的组织化学反应有助于正确地将肌病分类为HIV多发性肌炎或齐多夫定肌病。对HIV感染患者细胞因子表达以及补充肉碱等化合物或硒等微量营养素的研究，可能会为各种艾滋病相关肌肉疾病的发病机制和治疗带来新的见解。
